个人简介

杨琪，生物学博士，博士在读期间荣获博士一等奖学金、博士学业奖学金及优秀毕业生等荣誉。共发表SCI论文11篇，其中以第一/共一/通讯作者在中科院Top一区Cell Death & Disease、Oncogene、Journal of Experimental & Clinical Cancer Research等期刊发表SCI论文8篇。本人邮箱：yangqi_456@126.com

教育经历

2021/9-2025/6，河南大学，生物学，博士，导师，许志祥

2016/9-2018/6，河南大学，中药学，硕士，导师，万绍贵

2004/9-2008/6，河南农业大学，学士

工作经历

2025/7-至今，河南大学第一附属医院，科研人员

2018/8-2021/7，河南大学，表观遗传与转化医学实验室，科研助理

研究方向

肝癌及肿瘤免疫微环境

主持或参加的科研课题

1. 国家自然科学基金NSFC-河南联合基金培育项目，U1604167，游离线粒体IMOs作为肝癌液体活检标志物的临床应用及功能研究，2017/01- 2019/12，第四参与人；

2. 河南省科技攻关，182102310120，线粒体DNA变异在肝癌诊断中的作用及分子机制研究，2018/01-2019/12，第七参与人；

3. 河南省高等学校重点科研项目，17A310013，肝癌线粒体分裂异常促进TAM募集和极化的分子机制研究，2017/01-2018/12，第四参与人。

发表的期刊论文

1. Yang Qi#(第一作者); Cui Mengmeng#; Wang Jiaxin#; Zhao Yuan; Yin Weitao; Liao Ziqian; Liang Yixuan; Jiang Zhixiong; Li Yujia; Gu Jinrong; Qi Lixia; Chen Jiaxing; Zhao Jing; Bao Dengke*; Xu Zhi-Xiang*; Circulating mitochondrial DNA promotes M2 polarization of tumor associated macrophages and HCC resistance to sorafenib, Cell Death & Disease (IF = 9.5998, 中科院一区 TOP), 2025;16(1):153.
2. Zhao J, Cui M, Yao X, Jiang Z, Qi L, Chen J, Fan C, Bai S, Zhou C, Wei R, Liu H, Yang Q（共同通讯作者）, Wan L, Bao D. Targeting TFAM downregulation mediated mtDNA-NLRP3 pathway suppresses TAM infiltration and HCC progression(IF = 7.3003, 中科院一区). Oncogene. 2025 Jun 14.
3. Lei Jia#; Zhu Qingguo#; Guo Jianghao#; Chen Jiaxing; Qi Lixia; Cui Mengmeng; Jiang Zhixiong; Fan Chunhui; Wang Lin; Lai Tianjiao; Jin Yuxi; Si Lulu; Liu Yana; Yang, Qi*（共同通讯作者）; Bao Dengke*; Guo Ruixia*; TEFM facilitates uterine corpus endometrial carcinoma progression by activating ROS-NFκB pathway, Journal of Translational Medicine (IF = 7.4996, 中科院二区), 2024;22(1):1151.
4. Guo Sanxing; Li Fengying; Liang Yixuan; Zheng Yufei; Mo Yingyi; Zhao Deyao; Jiang Zhixiong; Cui Mengmeng; Qi Lixia; Chen Jiaxing; Wan Lixin; Chen Guoyong; Wei Sidong; Yang, Qi*（共同通讯作者）; Liu, Junqi*; AIFM2 promotes hepatocellular carcinoma metastasis by enhancing mitochondrial biogenesis through activation of SIRT1/PGC-1α signaling, Oncogenesis (IF = 5.9003, 中科院二区), 2023, 12(1): 46
5. Li Yujia#; Yang Qi#(共同第一作者); Chen Hui#; Yang Xiaotian; Han Jingru; Yao Xiaojuan; Wei Xiajie; Si Jiaoyang; Yao Huanling; Liu Hongliang; Wan Lixin; Yang Hushan*; Wang Yanming*; Bao Dengke*; TFAM downregulation promotes autophagy and ESCC survival through mtDNA stress-mediated STING pathway, Oncogene (IF = 8.0, 中科院一区 TOP), 2022; 41(30):3735-3746. 
6. Li Yujia#; Chen Hui#; Yang Qi#(共同第一作者); Wan Lixin; Zhao Jing; Wu Yuanyuan; Wang Jiaxin; Yang Yating; Niu Menglan; Liu Hongliang; Liu Junqi; Yang Hushan; Wan Shaogui*; Wang Yanming*; Bao Dengke*; Increased Drp1 promotes autophagy and ESCC progression by mtDNA stress mediated cGAS-STING pathway, Journal of Experimental & Clinical Cancer Research (IF = 11.2997, 中科院一区 TOP), 2022, 24;41(1):76. 
7. Yang Qi#(第一作者); Xi Jun#; Chen Xinxin; Hu Sihong; Chen Nan; Qiao Songlin; Wan Shaogui; Bao Dengke*. The development of a sensitive Droplet Digital PCR for Quantitative Detection of Porcine Reproductive and Respiratory Syndrome Virus. International Journal of Biological Macromolecules (IF = 3.9092, 中科院三区). 2017; 104:1223-1228.
8. Zhao Y, Liu MJ, Zhang L, Yang Q (其他作者), Sun QH, Guo JR, Lei XY, He KY, Li JQ, Yang JY, Jian YP, Xu ZX. High mobility group A1 (HMGA1) promotes the tumorigenesis of colorectal cancer by increasing lipid synthesis. Nat Commun.(IF = 14.7, 中科院一区) 2024 Nov 15;15(1):9909.
9. Bao Dengke#; Zhao Jing#; Zhou Xingchun#; Yang Qi (其他作者); Chen Yibing; Zhu Jianjun; Yuan Peng; Yang Jin; Qin Tao; Wan Shaogui*; Xing Jinliang*. Mitochondrial fission-induced mtDNA stress promotes tumor-associated macrophage infiltration and HCC progression, Oncogene (IF = 7.9712, 中科院一区 TOP), 2019, 38(25):5007-5020.
10. Bao Dengke#; Ba Yanna#; Zhou Feng; Zhao Jing; Yang Qi (其他作者); Ge Naijian; Guo Xu; Wu Zhenbiao; Zhang Hongxin; Wan Shaogui*; Xing Jinliang*. Alterations of telomere length and mtDNA copy number are associated with overall survival in hepatocellular carcinoma patients treated with transarterial chemoembolization, Cancer Chemotherapy and Pharmacology (IF = 2.7370, 中科院三区), 2016, 78(4):791-799. 
11. Li Jingyu#; Yang Qi#(共同第一作者); He Zhenkun#; Wang Yaqiang; Lin Xuhong; Li Yuanyuang; Bao Dengke*. The association between polymorphisms of class II cytokine receptor genes and risk of HBV-related hepatocellular carcinoma. International Journal of Clinical and Experimental Medicine (IF = 1.069, 中科院四区), 2017; 10(8): 12492-12500.