个人简介

李雅木，细胞生物学博士学位，助理教授， 2024年10月加入河南大学第一附属医院科研部，入选河南省“中原英才计划”青年组，联系方式：liyamu@henu.edu.cn。

教育经历

2010-2015 武汉大学 生命科学学院 博士

2006-2010 江汉大学 医学与生命科学学院 学士

工作经历

2024-至今 河南大学 第一附属医院  助理教授

2021-2024 美国Case Western Reserve University 研究科学家（Research Scientist），合作导师：Dr. Wang Zhenghe

2016-2021 美国Case Western Reserve University 博士后, 合作导师：Dr. Wang Zhenghe

研究方向

运用细胞分子生物学等技术、结合多种动物模型以及临床数据库，解析免疫细胞亚群在肝癌和结肠癌中的功能，探索在化疗干预过程中免疫细胞群体的深层次作用，为癌症的临床治疗提供强有力的理论支持。

发表论文

1: Wang Y, Shen F, Zhao C, Li J, Wang W, Li Y, Gan J, Zhang H, Chen X, Chen Q, Wang F, Liu Y, Zhou Y. Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining. Nucleic Acids Res. 2025 Mar 20;53(6):gkaf200. doi: 10.1093/nar/gkaf200. PMID: 40114375; PMCID:PMC11925728.（中科院2区，IF=13.1）

2: Rathore M, Curry K, Huang W, Wright M, Martin D, Baek J, Taylor D, Miyagi M,Tang W, Feng H, Li Y, Wang Z, Graor H, Willis J, Bryson E, Boutros CS, Desai O, Islam BN, Ellis LM, Moss SE, Winter JM, Greenwood J, Wang R. Leucine-Rich Alpha-2-Glycoprotein 1 Promotes Metastatic Colorectal Cancer Growth Through Human Epidermal Growth Factor Receptor 3 Signaling. Gastroenterology. 2025 Feb;168(2):300-315.e3. doi: 10.1053/j.gastro.2024.10.004. Epub 2024 Oct 10. PMID: 39393543; PMCID: PMC11769768. （中科院1区，IF=25.1）

3: Li Y, Wu S, Zhao Y, Dinh T, Jiang D, Selfridge JE, Myers G, Wang Y, Zhao X, Tomchuck S, Dubyak G, Lee RT, Estfan B, Shapiro M, Kamath S, Mohamed A, Huang SC, Huang AY, Conlon R, Krishnamurthi S, Eads J, Willis JE, Khorana AA, Bajor D, Wang Z. Neutrophil extracellular traps induced by chemotherapy inhibit tumor growth in murine models of colorectal cancer. J Clin Invest. 2024 Jan

9;134(5):e175031. doi: 10.1172/JCI175031. PMID: 38194275; PMCID: PMC10904055. （中科院1区，IF=15.9）

4: Li Y, Liu Z, Zhao Y, Yang J, Xiao TS, Conlon RA, Wang Z. PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain. Genes Dis. 2022 Dec 8;10(4):1702-1713. doi: 10.1016/j.gendis.2022.11.003. PMID: 37397533; PMCID: PMC10311099. （中科院2区，IF=6.8）

5: Hao Y#, He B#, Wu L#, Li Y#, Wang C, Wang T, Sun L, Zhang Y, Zhan Y, Zhao Y, Markowitz S, Veigl M, Conlon RA, Wang Z. Nuclear translocation of p85β promotes tumorigenesis of PIK3CA helical domain mutant cancer. Nat Commun. 2022 Apr 13;13(1):1974. doi: 10.1038/s41467-022-29585-x. PMID: 35418124; PMCID: PMC9007954. （#共一，中科院1区，IF=16.6）

6: Tian K, Wang A, Wang J, Li W, Shen W, Li Y, Luo Z, Liu Y, Zhou Y. Transcriptome Analysis Identifies SenZfp536, a Sense LncRNA that Suppresses Self-renewal of Cortical Neural Progenitors. Neurosci Bull. 2021 Feb;37(2):183-200. doi: 10.1007/s12264-020-00607-2. Epub 2020 Nov 16. PMID: 33196962; PMCID: PMC7870746. （中科院2区，IF=5.3）

7: Li W, Shen W, Zhang B, Tian K, Li Y, Mu L, Luo Z, Zhong X, Wu X, Liu Y, Zhou Y. Long non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b. Protein Cell. 2020 Mar;11(3):161-186. doi: 10.1007/s13238-019-0650-z. Epub 2019 Jul 17. PMID: 31317506; PMCID: PMC7026249. （中科院1区，IF=10.4）

8: Li Y, Wang W, Wang F, Wu Q, Li W, Zhong X, Tian K, Zeng T, Gao L, Liu Y, Li S, Jiang X, Du G, Zhou Y. Paired related homeobox 1 transactivates dopamine D2 receptor to maintain propagation and tumorigenicity of glioma-initiating cells. J Mol Cell Biol. 2017 Aug 1;9(4):302-314. doi: 10.1093/jmcb/mjx017. PMID:28486630; PMCID: PMC5907840. （中科院1区，IF=5.9）

9: Zhong X, Liu X, Li Y, Cheng M, Wang W, Tian K, Mu L, Zeng T, Liu Y, Jiang X, Yu L, Gao L, Zhou Y. HMGA2 sustains self-renewal and invasiveness of glioma-initiating cells. Oncotarget. 2016 Jul 12;7(28):44365-44380. doi:10.18632/oncotarget.9744. PMID: 27259253; PMCID: PMC5190103. （中科院2区，IF=5.1）

10: Lu B, Sun X, Chen Y, Jin Q, Liang Q, Liu S, Li Y, Zhou Y, Li W, Huang Z. Novel function of PITH domain-containing 1 as an activator of internal ribosomal entry site to enhance RUNX1 expression and promote megakaryocyte differentiation. Cell Mol Life Sci. 2015 Feb;72(4):821-32. doi:10.1007/s00018-014-1704-2. Epub 2014 Aug 19. PMID: 25134913; PMCID: PMC11113685. （中科院2区，IF=5.7）

11: Wang M, Gu B, Huang J, Jiang S, Chen Y, Yin Y, Pan Y, Yu G, Li Y, Wong BH, Liang Y, Sun H. Transcriptome and proteome exploration to provide a resource for the study of Agrocybe aegerita. PLoS One. 2013;8(2):e56686. doi: 10.1371/journal.pone.0056686. Epub 2013 Feb 13. PMID: 23418592; PMCID: PMC3572045. （中科院3区，IF=3.7）

12: Jiang S, Chen Y, Wang M, Yin Y, Pan Y, Gu B, Yu G, Li Y, Wong BH, Liang Y, Sun H. A novel lectin from Agrocybe aegerita shows high binding selectivity for terminal N-acetylglucosamine. Biochem J. 2012 Apr 15;443(2):369-78. doi: 10.1042/BJ20112061. PMID: 22268569; PMCID: PMC3316157. （中科院3区，IF=4.7）